Interferon Consensus Sequence Binding Protein Confers Resistance against Yersinia enterocolitica
نویسندگان
چکیده
منابع مشابه
Expression of interferon consensus sequence binding protein induces potent immunity against BCR/ABL-induced leukemia.
Mice deficient in the interferon consensus sequence binding protein (ICSBP) develop a disease resembling chronic myeloid leukemia (CML), which in humans is caused by the BCR/ABL oncoprotein. Interferon-alpha (IFN-alpha) induces ICSBP expression and is an effective therapy for CML. This study examined whether enforced expression of ICSBP might antagonize BCR/ABL-induced leukemia; results demonst...
متن کاملYersinia enterocolitica Serum Resistance Proteins YadA and Ail Bind the Complement Regulator C4b-Binding Protein
Many pathogens are equipped with factors providing resistance against the bactericidal action of complement. Yersinia enterocolitica, a Gram-negative enteric pathogen with invasive properties, efficiently resists the deleterious action of human complement. The major Y. enterocolitica serum resistance determinants include outer membrane proteins YadA and Ail. Lipopolysaccharide (LPS) O-antigen (...
متن کاملYersinia enterocolitica: pathogenesis, virulence and antimicrobial resistance.
Yersinia enterocolitica is a heterogeneous group of strains, which are classified into 6 biogroups, and into more than 57 O serogroups. However, the human pathogenic strains most frequently isolated worldwide belong to serogroups O:3, O:5,27, O:8 and O:9. The major route of Y. enterocolitica infection is through contaminated foods or water. The primary pathogenic event is colonization of the in...
متن کاملYersinia enterocolitica.
Characteristics of the disease Infectious dose is 10–100 organisms Incubation period is 1⁄2–4 (usually 1–3) days; up to a week for S. dysenteriae 1 Illness: diarrhea with fever and nausea; sometimes toxemia, vomiting, cramps, and tenesmus; dysentery—blood and mucus in stools; may cause hemolytic uremic syndrome; most severe in infants; mild and asymptomatic infections occur Duration: 4–7 days; ...
متن کاملInterferon consensus sequence binding protein (ICSBP; IRF-8) antagonizes BCR/ABL and down-regulates bcl-2.
BCR/ABL is the causative genetic aberration in chronic myelogenous leukemia (CML). Mice lacking expression of the interferon (IFN) consensus sequence binding protein (ICSBP), an IFN gamma-inducible transcription factor of the interferon regulatory factor (IRF) family, develop a disease similar to human CML. Mounting evidence suggests a role for ICSBP in the pathogenesis of CML. However, the und...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2000
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.68.3.1408-1417.2000